From frameworks to foresight
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Office of Health Economics | OHE

The Bulletin

Your biweekly update on health economics, policy, and impact

The promise and potential of cell and gene therapies, long-acting treatments, and a greener NHS.

  • The value of cell and gene therapies to the UK economy
  • Understanding the Full Value of Long-Acting Therapies: less is more?
  • Environmental sustainability in the NHS 10 Year Health Plan: The need for green 

Short on time? These are the highlights or our latest Bulletin or if you have a moment read more below.

Tim Watson

Tim Watson, Director

From frameworks to foresight: the economics of healthcare innovation

New life-saving treatments are on the horizon but they often challenge current payment frameworks: the US’ ‘Most Favoured Nation’ policy – and developments in the UK in response - make it clear that how to pay for healthcare is an increasingly pressing question.  

 

Balancing patient access with healthcare sustainability is central to our work at OHE. Our most recent publication presents a new method of quantifying the economic impact of healthcare innovations, such as cell and gene therapies. Our analysis supports the view of a system-shift towards cell and gene therapies as a definable investment option rather than an abstract aspiration. 

 

Similarly, we also looked at the potential of long-acting therapies to enhance patient outcomes and alleviate the strain on healthcare systems – our research makes the case for HTA frameworks to reflect the comprehensive benefits of these therapies to enable patient access and to incentivise innovation in this area. 

 

And to end on a celebratory note, we’d like to congratulate Adrian Towse, Emeritus Director and Visiting Senior Research Fellow at OHE, who has received the Avedis Donabedian Outcomes Research Lifetime Achievement Award from ISPOR. Adrian led OHE for over 25 years. His work has influenced health policy and economic thinking both at OHE and worldwide. We are delighted to be able to celebrate with him.  

The case for a UK system-shift in cell and
gene therapies

The value of cell and gene therapies to the UK economy

 

Our latest research shows improving access to cell and gene therapies (CGTs) across four key indications could generate over £20 billion in value over 10 years. Benefits include improved patient health, reduced NHS costs, and gains for the wider UK economy. The analysis highlights the potential of a coordinated CGT system-shift and the importance of strategic investment in infrastructure, workforce, and research.

Read the full analysis on the value of CGTs in the UK

Rethinking how health systems assess long-acting therapies

Understanding the Full Value of Long-Acting Therapies: less is more?

 

Long-acting therapies can improve outcomes for patients and ease pressure on health systems, but their broader benefits like productivity, patient choice, and environmental impact can be undervalued in HTA decisions. Adapting value frameworks to recognise these wider impacts could unlock innovation, support sustainable investment, and deliver better long-term outcomes.

See what’s holding back HTA evaluation of long acting therapies

The missing link in the NHS 10 Year Health Plan: climate and health

Environmental sustainability in the NHS 10 Year Health Plan: The need for green 

 

The NHS 10 Year Health Plan sets out goals for improving care and inequalities, but it doesn’t go far enough on climate action. Making sustainability central to health strategy is important for protecting both people and the planet.

See how sustainability shapes better health

OHE MSc fellowship in health economics

 

The OHE MSc Fellowship covers full tuition and provides a monthly stipend. Fellows work part-time at OHE while completing their MSc at City St George’s or UCL, gaining practical experience in applied health economics. The programme offers a route to develop research skills and a career at OHE.

 

Apply by 30 April 2026

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Office of Health Economics | OHE

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