How will biomedical markets respond?

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The Bulletin

Your biweekly update on health economics, policy, and impact

Changes to US drug prices will inevitably have consequences for global access and innovation.

  • ISPOR 2025 Plenary On Demand: Drug Price Controls— What Are the Unintended Consequences to Innovation?
  • The Trump Administration’s US Drug Pricing Proposal – What will happen next?
  • The Inflation Reduction Act: Price negotiation underway for the first 10 drugs

If that's all the time you have, we'll see you in the next Bulletin. If you have a few more minutes and want more context, keep going.

 

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Mikel-Berdud

Mikel Berdud,  Senior Principal Economist

US drug pricing policies will have global impacts on innovation and access

 

The knowledge generated through biomedical innovation is a public good. One person’s use does not reduce its availability to others. To incentivise private R&D investment, innovation is protected by intellectual property rights in the form of patents, during which time prices are regulated to balance incentives and access. 

 

Although pricing and reimbursement policies are set nationally, their impact can be global. This creates tension between short-term, country-level pricing strategies and the long-term global incentives needed to sustain innovation. 

 

In this interconnected context, national pricing policies impact global access, health system sustainability, and innovation incentives. These issues were central to the ISPOR 2025 Plenary, where OHE Chief Executive Graham Cookson spoke about the impact of the Inflation Reduction Act (IRA) and President Trump’s proposed Most Favoured Nation (MFN) policy. 

 

We also explored the potential implications of an MFN policy on innovation and access in one of our Insights last month, and we continue to monitor  

the global effects of the IRA. 

 

As U.S., European and global policy continue to evolve, OHE remains committed to contributing to this critical debate through evidence-based research. 

 

Unpacking the impact of drug price controls

What are the unintended consequences for innovation?

Held May 14 at ISPOR 2025 in Montreal, this session examined the ripple effects of drug price controls, including US policy shifts like the IRA and President Trump’s Executive Order introducing International Reference Pricing. 

Watch the session on demand

'Most Favoured Nation' policy - what next?

How industry and ex-US payers might react.

We explore a range of scenarios on how ex-US payers and pharmaceutical companies may respond, including changes to list price but not net price; global net prices converging and changes to commercial environment. 

Possible long-term outcomes

Will the IRA meet its policy objectives?

The Inflation Reduction Act: Price negotiation underway for the first 10 drugs

 

The first 10 drugs included in the Medicare Drug Price Negotiation Program created by the Inflation Reduction Act (IRA) were announced at the end of 2023. We discuss what they are, what they show us, and the potential ripple effects for R&D and patient access.

Read about the IRA's impact

Webinar:
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an Era of Climate Crisis

 

Join us at 10:00 BST on 8 July to hear how health economics can shape policy responses to the climate crisis. Gain insights from experts on applying economic evidence to support sustainable decisions.

 

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OHE Academy: Explaining the Inflation Reduction Act Program

 

Explore the technical detail of the US Inflation Reduction Act and understand how it relates to pharmaceutical payment and coverage. This material was produced with financial support from PhRMA. 

 

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